Kaizer Chiefs and Orlando Pirates will be without a total of 13 players for the Soweto derby with several key players out injured.
Both sides will be without players for a variety of injury reasons.
Kaizer Chiefs will have to do without the services of Leonard Castro, Lebogang Manyama, Samir Nurkovic, Siyabonga Ngezana, S’fiso Hlanti and Dumisani Zuma.
The Buccaneers are missing the likes of captain Happy Jele and Thembinkosi Lorch, Zakhele Lepasa, Innocent Maela, Richard Ofori, Vincent Pule and Wayne Sandilands.
Check out the gallery of players set to miss out on the Soweto derby:
Chiefs head coach Stuart Baxter is also injured, but will be on the sidelines cheering on his men from Naturena.
Amakhosi host the Buccaneers at the FNB Stadium on Saturday, 6 November.
Kick-off is at 15:30.